YMC-Pack DIOL-NP 50 mm x 4.6 mm x 5 um

Different Separation Characteristics from Bare Silica Gel

YMC-Pack Diol-NP shows typical normal-phase retention behavior when used with low-polarity mobile phases due to hydroxyl groups on the surface of the stationary phase acting as polar groups.  Diol-NP is as widely applicable to normal-phase separations as standard silica gel, but is useful in cases where separation optimization is difficult to achieve with silica.  In addition, it can also be used in HILIC-mode with organic/water mobile phases.

A Normal-Phase Alternative to Silica

YMC-Pack Diol-NP stationary phase is a versatile alternative to silica for normal-phase separations.  The bonded layer’s hydroxyl groups provide good selectivity without excessive retention, since hydrogen bonding with the Diol-NP layer is not as strong as with silanols on a bare silica surface.  Diol-NP columns also provide much better reproducibility when compared to bare silica material.

• Improved peak shape versus bare silica
• Good selectivity without excessive retention
• High product recovery
• Excellent bonded-phase reproducibility
• Long column lifetime
• High loading with prep material

Specifications

Column selection guide

• Column selection guide
• Guides for selecting C18 packing materials
• Guides for method development
• Strategy of method development for isolation/purification
• Technical information
• USP class

Application search

• Application search
• Application of nucleic acid
• Application of chiral compounds
• Application of antibody
• Application of SFC
• Application of amino acids/peptide/protein